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. 2005 Aug 11;568(Pt 2):381–396. doi: 10.1113/jphysiol.2005.092866

Figure 5. Alterations of kinetics of partial agonist-activated currents by the D298 mutations.

Figure 5

Traces show kinetics of currents activated by partial agonists, 2-Me-5-HT (100 μm) and dopamine (3 mm). A, activation elicited by 2-Me-5-HT (upper) and DA (lower). B, desensitization of currents activated by 2-Me-5-HT for 15 s (upper) and 3 mm DA for 20 s (lower). C, deactivation of currents activated by 2-Me-5-HT (upper) and DA for 10 ms (lower). The bar indicates the time of agonist application for activation and desensitization studies, and the straight arrow indicates the time point of application of agonists for 10 ms for deactivation study. Data are summarized in Table 2.