Table 2.

Kinetics of partial agonist-activated currents

	Activation		Desensitization		Deactivation
	τ (ms)	n	τ (ms)	n	τ (ms)	n
2-Me-5-HT
WT	259 ± 14	13	5653 ± 383	10	633 ± 38	14
D298A	54 ± 6**	11	3462 ± 223**	14	101 ± 5**	11
D298E	298 ± 12*	15	9730 ± 1352**	8	879 ± 53**	11
Dopamine
WT	543 ± 18	10	17967 ± 2575	9	184 ± 15	10
D298A	48 ± 6**	21	5685 ± 761**	11	69 ± 4**	7
D298E	832 ± 70**	14	23794 ± 2644	10	273 ± 17**	9

All data are given as mean ±s.e.m.

^*P < 0.05

^**P < 0.01, compared to WT.