Figure 1. Osmotic regulation of APD and I_to in mouse left ventricular apex myocytes.

A, superimposed representative action potential recordings under isosmotic (Iso, 305 mosmol kg⁻¹) and hyposmotic (Hypo, 235 mosmol kg⁻¹) conditions. B, original traces of whole-cell currents measured in the same cell as in panel A. a, superimposed representative whole-cell current traces recorded with the voltage protocols shown above, under isosmotic (Iso) and hyposmotic (Hypo) conditions. b, hyposmotic stress-sensitive current obtained by subtracting the current recorded under isosmotic (Iso) conditions from that under hyposmotic (Hypo) conditions.