Figure 5. Chloride transport activity of CFTR in VSMC with 5-hydroxytryptamine (5-HT).

The stimulation of iodide efflux as a function of time was evoked in solution containing 10 μm 5-HT by 10 μm forskolin plus 30 μm genistein without or with 100 μm CFTR_inh-172 as indicated for Cftr^+/+ mice (A) and Cftr^−/− mice (B). C, summary of the relative rates presented as means ±s.e.m. with statistical analysis. Basal was vehicle (DMSO). All experimental conditions have been repeated: n = 8. ***P < 0.001. ns: non significant difference.