Table 2.
Voltage dependence of inactivation of Nav1.2 and mutant sodium channels
| V1,½ (mV) | k (mV) | n | |
|---|---|---|---|
| Nav1.2 | −63.1 ± 0.3 | 8.1 ± 0.3 | 8 |
| R850E | −63.9 ± 0.3 | 7.2 ± 0.3 | 4 |
| R853E | −65.8 ± 0.8 | 9.3 ± 0.7 | 13 |
| E805R | −60.5 ± 1.5 | 9.9 ± 1.3 | 10 |
| D814R | −61.8 ± 0.4 | 6.3 ± 0.3 | 7 |
| E821R | −54.4 ± 9.4 | 9.4 ± 0.6 | 11 |
| D827R | −64.2 ± 1.1 | 8.2 ± 0.9 | 11 |
| D814R/R850E | −60.3 ± 0.7 | 9.6 ± 0.6 | 7 |
| D814R/R853E | −62.9 ± 0.9 | 8.2 ± 0.8 | 10 |
| E821R/R850E | −65.6 ± 0.3 | 7.5 ± 0.2 | 9 |
| E821R/R853E | −58.7 ± 0.5 | 9.1 ± 0.5 | 4 |