Figure 1.

Phylogeny of NRKs. Amino acid sequences of kinase domains of NRKs and other serine-threonine kinases were aligned and a neighbor-joining tree prepared using HsCdk2 as an outgroup. Numbers above branches represent bootstrap support values above 50%. The multiple sequence alignment is shown in Supplemental Figure S6. Novel motifs found downstream of the kinase domain of Cnk2p type NRKs are shown in Supplemental Figure S7.