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Model of Sec2p function. Sec2p is recruited to secretory vesicles by its interaction with Ypt32p. On the vesicle, Sec2p activates Sec4p. Activated Sec4p in turn recruits its effector Sec15p, which displaces Ypt32p from its binding site on Sec2p. Under normal conditions, Sec2p is released from the exocyst after vesicle tethering. Sec2p mutants defective in the amino acid region 451-508 display increased binding to Sec15p and cannot recycle, which results in mislocalization of Sec2p.
