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. 2006 Jun 8;116(7):2022–2032. doi: 10.1172/JCI28423

Figure 10. Schematic diagram of the innate effects of HSP60 on Treg function.

Figure 10

The exposure of Tregs to HSP60 via innate TLR2 signaling amplifies their response to TCR-dependent (anti-CD3) stimulation, reflected by upregulation of AKT, Pyk2, and p38 and downregulation of ERK. These innate effects of HSP60 signaling amplify IL-10, TGF-β, and contact-dependent Treg suppressor mechanisms that impinge on TCR-activated CD4+CD25– T cells to downregulate ERK, NF-κB, and T-bet, leading, in turn, to downregulated proliferation and secretion of the proinflammatory cytokines IFN-γ and TNF-α and to upregulation of IL-10 secretion.