Abstract
In addition to the usual toxicology studies necessary for the safe manufacture and use of polymers at room temperature, special studies are needed for polymers which will be used at elevated temperatures. This paper discusses various areas to be investigated and principles for deciding on test materials, tests, and test conditions, polytetrafluoroethylene (PTFE) and fluorinated polyethylene-propylene (PFEP) pyrolysis studies being used as an illustrative case history. Some limitations of animal testing also are mentioned. A toxicological spectrum relating toxicological determinants to PTFE temperature is developed.
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- CAVAGNA G., FINULLI M., VIGLIANI E. C. [Experimental study on the pathogenesis of fevers caused by the inhalation of Teflon (polytetrafluoroethylene) fumes]. Med Lav. 1961 Apr;52:251–261. [PubMed] [Google Scholar]
- CLAYTON J. W., Jr, DELAPLANE M. A., HOOD D. B. Toxicity studies with octafluorocyclobutane. Am Ind Hyg Assoc J. 1960 Oct;21:382–388. doi: 10.1080/00028896009344090. [DOI] [PubMed] [Google Scholar]
- Coleman W. E., Scheel L. D., Gorski C. H. The particles resulting from polytetrafluoroethylene (PTFE) pyrolysis in air. Am Ind Hyg Assoc J. 1968 Jan-Feb;29(1):54–60. doi: 10.1080/00028896809342981. [DOI] [PubMed] [Google Scholar]
- Coleman W. E., Scheel L. D., Kupel R. E., Larkin R. L. The identification of toxic compounds in the pyrolysis products of polytetrafluoroethylene (PTFE). Am Ind Hyg Assoc J. 1968 Jan-Feb;29(1):33–40. doi: 10.1080/00028896809342978. [DOI] [PubMed] [Google Scholar]
- Griffith F. D., Stephens S. S., Tayfun F. O. Exposure of Japanese quail and parakeets to the pyrolysis products of fry pans coated with Teflon and common cooking oils. Am Ind Hyg Assoc J. 1973 Apr;34(4):176–178. doi: 10.1080/0002889738506828. [DOI] [PubMed] [Google Scholar]
- HARRIS D. K. Polymer-fume fever. Lancet. 1951 Dec 1;2(6692):1008–1011. doi: 10.1016/s0140-6736(51)93401-0. [DOI] [PubMed] [Google Scholar]
- Schell L. D., Lane W. C., Coleman W. E. The toxicity of polytetrafluoroethylene pyrolysis products including carbonyl fluoride and a reaction product, silicon tetrafluoride. Am Ind Hyg Assoc J. 1968 Jan-Feb;29(1):41–48. doi: 10.1080/00028896809342979. [DOI] [PubMed] [Google Scholar]
- Waritz R. S., Kwon B. K. The inhalation toxicity of products of polytetrafluoroethylene heated below 500 degrees centigrade. Am Ind Hyg Assoc J. 1968 Jan-Feb;29(1):19–26. doi: 10.1080/00028896809342976. [DOI] [PubMed] [Google Scholar]