. Author manuscript; available in PMC: 2006 Jun 7.

Published in final edited form as: J Toxicol Clin Toxicol. 2004;42(6):865–875. doi: 10.1081/clt-200035223

Table 2.

Atropine recommendations in major textbooks of internal medicine and national formularies.

Source	Edition / Year	Recommended regimen to attain atropinisation	Markers of atropinisation	Max dose of atropine first 24h
Australian Medicines Handbook ⁵⁴	4^th / 2003	2 mg IV repeated as necessary until patient is atropinised, then infusion titrated against clinical effects.	Abolish all secretions	maximum dose may be >50- 100 mg/hour
British National Formulary ⁵³	46^th / 2003	2mg, repeated every 5-10 min (IM or IV according to severity)	Dry flushed skin, dilated pupils, tachycardia	NG
Davidsons ⁵⁵	19^th / 2002	2mg, repeated every 10 min	Dry secretions, reversal of bradycardia	30mg, rarely more
Harrisons ⁵⁶	15^th / 2001	0.5-2mg, repeated every 5-15 min	Dry secretions	NG
Oxford Textbook of Medicine ⁵⁷	4^th / 2003	2mg, repeated every 10-30 min	No bronchorrhoea & bronchospasm, or flushed dry skin, dry mouth, tachycardia	30mg, occasionally much more
WHO Model Formulary ⁵²	1^st / 2002	2mg, repeated every 20-30 min	Flushed dry skin and tachycardia	NG