Table 2.
Independent predictors of self selected regular use of nonsteroidal antiinflammatory drugs in 22,043 male physicians
| Non-aspirin NSAIDs | Any NSAIDs | |||
|---|---|---|---|---|
| OR* | 95% CI* | OR* | 95% CI* | |
| Age (years) | ||||
| 40 – < 50 | 1.0 | reference | 1.0 | reference |
| 50 – < 60 | 2.1 | 1.9 – 2.3 | 2.8 | 2.6 – 3.0 |
| 60 – < 70 | 2.6 | 2.3 – 2.9 | 5.4 | 5.0 – 5.9 |
| 70 – < 80 | 2.5 | 2.2 – 2.9 | 7.0 | 6.4 – 7.6 |
| 80 – < 90 | 1.9 | 1.6 – 2.3 | 7.0 | 6.3 – 7.8 |
| 90 + | 1.5 | 1.1 – 2.2 | 8.2 | 6.5 – 10 |
| Body mass index (kg/m2)† | ||||
| < 25 | 1.0 | reference | 1.0 | reference |
| 25 – < 30 | 1.3 | 1.2 – 1.4 | 1.2 | 1.2 – 1.2 |
| 30 + | 1.9 | 1.7 – 2.1 | 1.6 | 1.5 – 1.7 |
| Vigorous exercise‡ | ||||
| Less than once per week | 1.0 | reference | 1.0 | reference |
| 1–4 times per week | 1.2 | 1.1 – 1.2 | 1.2 | 1.1 – 1.2 |
| 5 or more times per week | 1.2 | 1.1 – 1.3 | 1.3 | 1.2 – 1.4 |
| Smoking | ||||
| Never | 1.0 | reference | 1.0 | reference |
| Past | 1.1 | 1.0 – 1.2 | 1.0 | 1.0 – 1.1 |
| Current | 0.9 | 0.8 – 1.1 | 0.8 | 0.7 – 0.8 |
| Alcohol consumption | ||||
| Never/rarely | 1.0 | reference | 1.0 | reference |
| 1–3 times per month | 1.0 | 0.9 – 1.1 | 1.1 | 1.0 – 1.1 |
| Once per week | 1.1 | 1.0 – 1.3 | 1.1 | 1.0 – 1.2 |
| 2–4 times per week | 1.1 | 1.0 – 1.3 | 1.2 | 1.1 – 1.3 |
| 5–6 times per week | 1.2 | 1.1 – 1.3 | 1.2 | 1.1 – 1.3 |
| Daily | 1.3 | 1.2 – 1.4 | 1.1 | 1.1 – 1.2 |
| Multivitamin use | 1.5 | 1.5 – 1.6 | 1.7 | 1.7 – 1.8 |
| Vegetables (servings per day) | 0.91 | 0.88 – 0.94 | 0.80 | 0.78 – 0.81 |
| Fruits (servings per day) | 0.92 | 0.88 – 0.96 | 0.87 | 0.84 – 0.89 |
| Comorbidity | ||||
| Hypertension§ | 1.0 | 1.0 – 1.1 | 1.1 | 1.1 – 1.2 |
| Diabetes | 1.0 | 0.8 – 1.1 | 1.1 | 1.0 – 1.2 |
| Coronary artery disease¶ | 1.8 | 1.5 – 2.0 | 3.8 | 3.4 – 4.3 |
| Angina | 1.2 | 1.1 – 1.4 | 1.6 | 1.5 – 1.8 |
| Arthritis | 3.9 | 3.6 – 4.1 | 1.9 | 1.8 – 2.0 |
| Headaches** | 1.3 | 1.3 – 1.4 | 1.7 | 1.6 – 1.7 |
| Migraine** | 1.2 | 1.0 – 1.3 | 1.3 | 1.2 – 1.3 |
| Peptic ulcer | 0.7 | 0.6 – 0.9 | 0.8 | 0.7 – 0.9 |
| Gastrointestinal bleeding | 1.1 | 1.0 – 1.2 | 1.1 | 1.1 – 1.2 |
| Gastritis | 1.4 | 1.3 – 1.5 | 1.5 | 1.5 – 1.6 |
Odds ratios and their 95% confidence intervals for use of non-aspirin NSAIDs (left columns) and non-aspirin NSAIDs or aspirin (right columns) on more than 60 days per year from generalized estimating equation model based on 324,415 individual questionnaires adjusting for intra-individual dependence of multiple (up to 20) questionnaires per person and all variables in the table
Weight in kilograms divided by squared height in meters
Vigorous enough to work up a sweat
Systolic or diastolic blood pressure ≥ 140/90, respectively, or use of antihypertensives
Myocardial infarction, coronary artery bypass grafting, or percutaneous transluminal coronary angioplasty
Any mention of headache or migraine (specific questions, not assessed at baseline)