Table 3.
Age-adjusted | Fully-adjusted* without arthritis | Fully-adjusted* including arthritis | |||||||
---|---|---|---|---|---|---|---|---|---|
Duration of regular non-aspirin NSAID use after initiation | Person-years | Events | IR per 100,000 p-y | RR | 95% CI | RR | 95% CI | RR | 95% CI |
Never | 311,615 | 411 | 132 | 1.0 | reference | 1.0 | reference | 1.0 | reference |
1 year | 26,235 | 43 | 164 | 1.1 | 0.8 – 1.5 | 1.1 | 0.8 – 1.5 | 1.1 | 0.8 – 1.6 |
2 years | 10,411 | 15 | 144 | 0.9 | 0.5 – 1.5 | 0.9 | 0.5 – 1.5 | 1.0 | 0.6 – 1.7 |
3 years | 5,814 | 9 | 155 | 1.0 | 0.5 – 1.8 | 0.9 | 0.5 – 1.8 | 1.1 | 0.5 – 2.1 |
4 years | 3,802 | 6 | 158 | 1.0 | 0.4 – 2.1 | 0.9 | 0.4 – 2.0 | 1.0 | 0.5 – 2.3 |
5 or more years | 7,947 | 11 | 138 | 0.9 | 0.5 – 1.6 | 0.8 | 0.4 – 1.5 | 0.9 | 0.5 – 1.7 |
Duration of regular all NSAIDs use after initiation | |||||||||
Never | 240,900 | 307 | 127 | 1.0 | reference | 1.0 | reference | 1.0 | reference |
1 year | 42,649 | 57 | 134 | 0.9 | 0.7 – 1.2 | 0.9 | 0.6 – 1.2 | 0.9 | 0.6 – 1.2 |
2 years | 24,911 | 36 | 145 | 0.9 | 0.6 – 1.3 | 0.9 | 0.6 – 1.3 | 0.9 | 0.6 – 1.3 |
3 years | 17,176 | 22 | 128 | 0.7 | 0.5 – 1.2 | 0.7 | 0.4 – 1.1 | 0.7 | 0.5 – 1.2 |
4 years | 12,108 | 23 | 190 | 1.2 | 0.7 – 1.8 | 1.1 | 0.7 – 1.7 | 1.2 | 0.7 – 1.9 |
5 or more years | 28,079 | 50 | 178 | 1.0 | 0.7 – 1.4 | 0.9 | 0.7 – 1.4 | 1.0 | 0.7 – 1.5 |
Rate ratios and their 95% confidence intervals from time-varying Cox proportional hazards model controlling for all variables presented in table 2: age (continuous, linear and squared), body mass index (continuous), vigorous exercise (5 categories), smoking (never, former, current), alcohol consumption (6 categories), multivitamin use, consumption of fruits and vegetables (servings per day, continuous), as well as history of hypertension, diabetes, coronary artery disease (myocardial infarction, coronary artery bypass grafting, or percutaneous transluminal coronary angioplasty), angina, headache, migraine, peptic ulcer, gastrointestinal bleeding, and gastritis; variables are updated during follow-up whenever possible