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. 2002;4(Suppl 3):S26–S38.

Table 1.

Phosphodiesterase Family Tree (11 Families, 21 Subfamilies, 53 Isoforms)

Phosphodiesterase Subfamily Splice Variants
Family
All 1 A 4
discovered 1 B 1
pre-sildenafil 1 C 5
2 A 3
3 A 1
3 B 1
4 A 8
4 B 3
4 C 4
4 D 5
5 A 3
6 A 1
6 B 1
6 C 1
All 7 A 3
discovered 7 B 1
post-sildenafil 8 A 1
8 B 1
9 A 4
10 A 2
11 A 4