Table 1.
Retrovirus | Adenovirus | Adeno-associated virus | Liposome | |
---|---|---|---|---|
Advantages | Stable integration | High virus titer | Integrates into chromosome 19 | Less immunogenic |
Large insert capacity | Highly efficient transfer | Targets nondividing cells | ||
Biology well investigated | Targets nondividing cells | |||
Disadvantages | Low titer | Host immune response | Biology not well known | Low efficient transfer |
Infects only dividing cells | Transient expression | Small insert capacity | ||
Application | Ex vivo strategy | Direct injection | Direct injection | Direct injection |
Initially well used | Ex vivo transfer |