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. 2001 Fall;3(4):179–186.

Table 2.

Cancer Gene Therapy: Strategies

  1. Tumor supperssor gene therapy

    Reversal of malignant phenotype by introducing normal tumor suppressor gene p53, Rb (retinoblastoma), p21

  2. Suicide gene therapy

    Activation of prodrug in transfected cells herpes simplex thymidine kinase (HSV-tk) plus ganciclovir (GCV) cytosine deaminase plus 5-fluorocytosine (5-FC)

  3. Immunomodulatory gene therapy

    Induction and enhancement of tumor-specific immune response ex vivo (tumor vaccine) in vivo

  4. Anti-oncogene therapy

    Antisense oligonucleotides strategy to downregulate gene expression c-myc, ras

  5. Oncolytic virus therapy

    adenovirus (CN-706, ONYX-015) herpes simplex virus (G-207) retrovirus