Table 1.

Outcome Data from a Study of Transurethral Collagen Injection for Urinary Incontinence

Authors	Patient Population	Results	Conclusions	Comments/Findings
McGuire and Appell,	98 women, 89 men	Over 1 y:	Collagen injection dramatically	Urethral leakage that results
199416	over 1 y;	ISD women:	improves the ability of the	when abdominal pressure
	45 women, 33 men	Base ALPP:	urethra to resist abdominal	is elevated indicates
	at 2-y follow-up	29 cm H2O	pressure without changing	dysfunction due to poor
		Last ALPP	voiding pressure required	closure mechanism or
		w/collagen:	to induce voiding.	urethral hypermobility.
		66 cm H2O
		ISD men:	Injectable materials should	Surgery designed to restore
		Base ALPP:	not be considered a	and hold the urethra in
		43 cm H2O	minor treatment for	normal position during
		Last ALPP	minor incontinence, nor	high abdominal pressure
		w/collagen:	should they be considered	does not often resolve
		70 cm H2O	competitive with other	leakage due to poor
		At 2 y:	treatments, including	closure mechanism.
		ISD women:	pubovaginal slings.
		Base ALPP:		Generally, leakage at very
		30 cm H2O	Injectables can be used in	low abdominal pressures
		Last ALPP	conjunction with slings	indicates poor proximal
		w/collagen:	or artificial sphincters.	urethral sphincter
		90 cm H2O		function
		ISD men:
		Base ALPP:		Patients with improvement
		34 cm H2O		often did not want or
		Last ALPP		need further therapy.
		w/collagen:
		101 cm H2O		Complete dryness is not
				always necessary for
				success.

ISD, intrinsic sphincteric deficiency; ALPP, abdominal leak point pressure.