Table 3.

Outcome Data from Three Studies of Transurethral Collagen Injection for Male Urinary Incontinence

	Patient
Authors	Population	Results	Conclusions	Comments/Findings
Elsergany and Ghoniem,	35 men with ISD	20 % dry	Transurethral collagen	Procedures were performed
199823	(mean age 69 y)	31 % improved	injection is a safe and	under local anesthesia
	followed for 3–22	49% no improvement	reasonable option	with monitored
	mo (mean 18 mo)	Average volume used	for men with ISD.	anesthesia care.
		for dry/improvement
		cases: 8.2 mL,	History of pelvic	Abdominal leak point
		2 sessions	irradiation, urethral	pressure increased
			stricture, or involuntary	significantly after
			bladder contractions	injection, from 69 cm
			can jeopardize results.	H2O to 116 cm H2O.
				Complications are low.
Cummings et al,	19 men with post-	21 % dry	Collagen injection can
199624	radical prostatec-	37 % improved	be helpful for men
	tomy stress incon-	42 % no improvement	with stress incon-
	tinence, followed	Average volume used	tinence induced by
	for 3–15 mo	for dry/improved	radical prostatectomy.
	(mean 10 mo)	cases: 13.8 mL,
		1.8 sessions	Tissue scarring and
			preoperative severity
			of leakage affect results.
Aboseif et al, 199622	88 men with ISD	48 % dry	Transurethral collagen	Collagen was injected
	(men age 68 y)	37 % improved	injection is effective	slowly, under direct
	followed for	15 % no improvement	and safe in carefully	supervision, on both
	6–12 mo (mean	Average volume	selected patients	sides until coaptation
	10 mo)	used for dry/	with ISD.	was achieved.
		improved cases:
		22.7 mL, 3.4	Tissue scarring and	Treatment endpoint
		sessions	preoperative severity	was cure of 5
			of leakage affected	injections.
			outcomes.
				Most injections were
			No significant	performed under
			morbidity is	local anesthesia.
			associated with
			collagen injection.

ISD, intrinsic sphincteric deficiency.