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Cells are able to exit from mitosis when any single one of the three Clb2-inhibiting mechanisms is faulty. Top panel, constitutive transcription of CLB2 in G1 phase. Middle panel, no Hct1-mediated degradation of Clb2 at telophase. Bottom panel, no Sic1 to inhibit Clb2/Cdc28 in G1 phase. The arrow on the ordinate indicates mass at division; all three strains have size comparable with wild type.
