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Hypothetical model of cooperative protein folding by Hsp70 and Hsp110. Sequence signatures in an unfolded multidomain protein are recognized by either Hsp70 or Hsp110. Concerted release of Hsp70 and Hsp110 triggers efficient folding of domain A (i.e., a structural unit that folds cooperatively), and subsequent release of Hsp70 triggers folding of domain B.
