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. 2006 Jun 1;25(11):2615–2622. doi: 10.1038/sj.emboj.7601167

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Copyright © 2006, European Molecular Biology Organization

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p53^S18/23A mutation completely rescues the embryonic lethality of Xrcc4^−/− mice. (A) The number of offspring in various genotypes derived from the following breeding: Xrcc4^+/−p53^S18/23A/+ × Xrcc4^+/−p53^S18/23A/+ or Xrcc4^+/−p53^S18/23A × Xrcc4^+/−p53^S18/23A. The expected number based on the Mendelian ratio is also shown. (B) The number of offsprings in various genotypes derived from either Xrcc4^+/−p53^S18A/+ × Xrcc4^+/−p53^S18A/+ or Xrcc4^+/−p53^S18A × Xrcc4^+/−p53^S18A breeding. (C) p53-dependent apoptosis in the embryonic cerebral cortex as shown by ISEL+. Saggital sections from E12.5 embryos were shown. The apoptotic cells are indicated by arrowheads. (D) The surviving percentage of Xrcc4^+/−p53^S18/23A (n=16), Xrcc4^−/−p53^S18/23A/+ (n=10) and Xrcc4^−/−p53^S18/23A (n=34) mice at various times after birth. N represents the number of mice monitored. P-value is 0.0004 for the comparison between Xrcc4^−/−p53^S18/23A/+ and Xrcc4^+/−p53^S18/23A mice and 0.001 for the comparison between Xrcc4^−/−p53^S18/23A and Xrcc4^+/−p53^S18/23A mice.