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Aging p53S18/23A mice are prone to spontaneous cancer. (A) Survival curve of 20 pairs of WT and p53S18/23A mice. P-value is 0.04 for the comparison of the survival rate of p53S18/23A mice and WT controls. Animals were monitored for spontaneous tumorigenesis over the course of 2 years. (B) The spectrum of tumors developed in p53S18/23A mice.
