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The reaction of the buffering SERCA pump to a change in cytosolic calcium concentration. The ER calcium concentration is fixed at 185.9 μmol/L ER. Pt = 15 μmol/L Cyt and the cytosolic calcium concentration is stepped up from 0 to 1 μmol/L Cyt as shown in the inset in panel A. (A) The flux of calcium from the cytosol onto the SERCA pump. (B) The flux of calcium from the pump, into the ER. Note that the units used are μmol/L Cyt/s for comparison with the plot in panel A.
