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Percentage of the 69 nonpregnant women with a minimum plasma concentration above 1 mg/liter as a function of daily dose and frequency of administration. Solid curve, twice-daily regimen (BID); dotted curve, thrice-daily regimen (TID). The vertical lines denote the minimal FDA-recommended doses: 1,250 mg BID (solid line) or 750 mg TID (dotted line).
