TABLE 3.
Year-to-year changes in nonsusceptible and multidrug-resistant S. pneumoniae isolates during 11-year study
| Yr | % of nonsusceptible isolates (no. intermediate/resistant)a
|
Total no. of isolates | % (no.) of isolates with MDR | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| PEN | CRO | CTX | TET | ERY | CLI | CHL | CIP | OFX | |||
| 1994 | 12.0 (2/1) | 4.0 (1/0) | 8.0 (2/0) | 8.0 (1/1) | 4.0 (0/1) | 4.0 (1/0) | 4.0 (NA/1) | ND | 4.0 (0/1) | 25 | 4.0 (1) |
| 1995 | 20.0 (13/1) | 2.9 (1/1) | 2.9 (1/1) | 10.0 (0/7) | 5.7 (0/4) | 2.9 (0/2) | 4.3 (NA/3) | ND | 4.3 (3/0) | 70 | 2.9 (2) |
| 1996 | 14.5 (4/5) | 4.8 (3/0) | 8.1 (5/0) | 11.3 (0/7) | 4.8 (0/3) | 4.8 (0/3) | 6.5 (NA/4) | ND | 4.8 (3/0) | 62 | 8.2 (5) |
| 1997 | 18.2 (8/4) | 4.5 (3/0) | 7.6 (4/1) | 9.1 (1/5) | 7.6 (0/5) | 6.1 (0/4) | 0.0 (NA/0) | ND | 1.5 (1/0) | 66 | 6.3 (4) |
| 1998 | 17.4 (8/0) | 2.2 (1/0) | 0.0 (0/0) | 4.3 (0/2) | 13.0 (0/6) | 6.5 (0/3) | 2.2 (NA/1) | ND | 2.2 (1/0) | 46 | 11.4 (5) |
| 1999 | 16.6 (19/10) | 2.9 (5/0) | 2.3 (5/0) | 8.7 (1/14) | 12.7 (0/22) | 9.2 (0/16) | 1.2 (NA/2) | 1.2 (NA/2) | 1.2 (0/2) | 175 | 4.6 (8) |
| 2000 | 28.5 (35/4) | 2.9 (3/1) | 4.4 (5/1) | 13.1 (2/16) | 11.7 (1/15) | 10.9 (0/15) | 2.2 (NA/3) | 0.0 (NA/0) | 0.0 (0/0) | 137 | 6.6 (9) |
| 2001 | 22.9 (37/4) | 2.2 (4/0) | 2.2 (4/0) | 11.2 (0/20) | 16.8 (0/30) | 11.7 (0/21) | 2.2 (NA/4) | 0.6 (NA/1) | 1.1 (2/0) | 179 | 7.3 (13) |
| 2002 | 21.1 (42/2) | 1.4 (3/0) | 1.4 (3/0) | 10.0 (1/20) | 12.0 (0/25) | 7.7 (0/16) | 2.9 (NA/6) | 0.5 (NA/1) | 0.0 (0/0) | 209 | 7.9 (16) |
| 2003 | 17.7 (28/1) | 0.0 (0/0) | 0.0 (0/0) | 17.7 (3/26) | 20.1 (2/31) | 13.0 (2/19) | 3.1 (NA/5) | 1.8 (NA/3) | 1.2 (2/0) | 164 | 11.8 (19) |
| 2004 | 23.2 (44/2) | 0.5 (1/0) | 0.5 (1/0) | 18.2 (1/35) | 23.2 (4/42) | 11.4 (0/22) | 3.6 (NA/7) | 3.5 (NA/7) | 5.7 (10/1) | 198 | 15.6 (30) |
| Total | 20.6 (240/34) | 2.0 (25/2) | 2.4 (30/3) | 12.3 (10/153) | 14.4 (7/184) | 9.4 (3/121) | 2.7 (NA/36) | 1.4 (NA/15) | 2.0 (22/4) | 1,331 | 8.6 (112) |
a
PEN, penicillin; CRO, ceftriaxone; CTX, cefotaxime; TET, tetracycline; ERY, erythromycin; CLI, clindamycin; CHL, chloramphenicol; CIP, ciprofloxacin; OFX, ofloxacin. NA, not applicable; ND, not determined.