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. 2006 Jun;50(6):2098–2105. doi: 10.1128/AAC.00198-06

TABLE 4.

Serotype distribution of S. pneumoniae isolates that were nonsusceptible to different antimicrobial agents from 1994 to 2004

Antimicrobial agent and period No. (%) of isolates with pneumococcal serogroup/type:
Total
1 3 6 7 9 14 15 17 19 23 24 33 Othersa NDb
Penicillin
    1994-1998 0 3 (6.5) 0 7 (15.2) 20 (43.5) 1 (2.2) 0 3 (6.5) 10 (21.7) 0 2 (4.3) 0 46
    1999-2001 0 7 (6.4) 1 (0.9) 17 (15.6) 58 (53.2) 1 (0.9) 0 5 (4.6) 19 (17.4) 0 1 (0.9) 0 109
    2002-2004 1 (0.8) 4 (3.4) 0 10 (8.4) 37 (31.1) 5 (4.2) 1 (0.8) 26 (21.8) 16 (13.4) 2 (1.7) 0 17 (14.3) 119
    Total 1 (0.4) 14 (5.1) 1 (0.4) 34 (12.4) 115 (42.0) 7 (2.6) 1 (0.4) 34 (12.4) 45 (16.4) 2 (0.7) 3 (1.1) 17 (6.2) 274
Cefotaxime
    1994-1998 0 4 (28.6) 6 (42.9) 0 4 (28.6) 14
    1999-2001 1 (7.1) 4 (28.6) 9 (64.3) 0 0 14
    2002-2004 0 0 3 (75) 1 (25) 0 4
    Total 1 (3.1) 8 (25) 18 (56.3) 1 (3.1) 4 (12.5) 32
Ceftriaxone
    1994-1998 0 3 (30) 3 (30) 1 (10) 3 (30) 10
    1999-2001 1 (7.7) 4 (30.8) 8 (61.5) 0 0 13
    2002-2004 0 0 3 (75) 1 (25) 0 4
    Total 1 (3.7) 7 (25.9) 14 (51.9) 2 (7.4) 3 (11.1) 27
Erythromycin
    1994-1998 0 0 7 (36.8) 0 1 (5.3) 6 (31.6) 1 (5.3) 0 2 (10.5) 1 (5.3) 0 0 1 (5.3) 0 19
    1999-2001 0 2 (2.9) 20 (29.4) 2 (2.9) 3 (4.4) 21 (30.9) 3 (4.4) 0 12 (17.6) 3 (4.4) 0 1 (1.5) 1 (1.5) 0 68
    2002-2004 1 (1.0) 0 10 (9.6) 0 3 (2.9) 21 (20.2) 5 (4.8) 1 (1.0) 28 (26.9) 2 (1.9) 2 (1.9) 4 (3.8) 1 (1.0) 26 (25.0) 104
    Total 1 (0.5) 2 (1.0) 37 (19.4) 2 (1.0) 7 (3.7) 48 (25.1) 9 (3.1) 1 (0.5) 42 (22.0) 6 (3.1) 2 (1.0) 5 (2.6) 3 (1.6) 26 (13.6) 191
Clindamycin
    1994-1998 0 7 (53.8) 0 0 1 (7.7) 1 (7.7) 0 2 (15.4) 1 (7.7) 0 0 1 (7.7) 0 13
    1999-2001 2 (3.8) 17 (32.7) 1 (1.9) 0 14 (26.9) 2 (3.8) 0 12 (23.1) 3 (5.8) 0 1 (1.9) 0 (0.0) 0 52
    2002-2004 0 9 (15.3) 0 2 (3.4) 4 (6.8) 5 (8.5) 1 (1.7) 17 (28.8) 2 (3.4) 2 (3.4) 4 (6.8) 1 (1.7) 12 (20.3) 59
    Total 2 (1.6) 33 (26.6) 1 (1.8) 2 (1.6) 19 (15.3) 8 (6.5) 1 (0.8) 31 (25.0) 6 (4.8) 2 (1.6) 5 (4.0) 2 (1.6) 12 (9.7) 124
Ciprofloxacin
    1994-1998 0 0 0 0 1 (100) 0 1
    1999-2001 1 (33.3) 0 2 (66.7) 0 0 (33.3) 0 3
    2002-2004 1 (9.1) 1 (9.1) 2 (18.2) 1 (9.1) 1 (9.1) 5 (45.5) 11
    Total 2 (13.3) 1 (6.7) 4 (26.7) 1 (6.7) 2 (13.3) 5 (33.3) 15
a

Includes serogroups/types 4 (n = 1), 8 (n = 1), 10 (n = 1), 11 (n = 1); 22 (n = 1), and 34 (n = 1).

b

Not determined.