TABLE 4.
Serotype distribution of S. pneumoniae isolates that were nonsusceptible to different antimicrobial agents from 1994 to 2004
| Antimicrobial agent and period | No. (%) of isolates with pneumococcal serogroup/type:
|
Total | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 3 | 6 | 7 | 9 | 14 | 15 | 17 | 19 | 23 | 24 | 33 | Othersa | NDb | ||
| Penicillin | |||||||||||||||
| 1994-1998 | 0 | 3 (6.5) | 0 | 7 (15.2) | 20 (43.5) | 1 (2.2) | 0 | 3 (6.5) | 10 (21.7) | 0 | 2 (4.3) | 0 | 46 | ||
| 1999-2001 | 0 | 7 (6.4) | 1 (0.9) | 17 (15.6) | 58 (53.2) | 1 (0.9) | 0 | 5 (4.6) | 19 (17.4) | 0 | 1 (0.9) | 0 | 109 | ||
| 2002-2004 | 1 (0.8) | 4 (3.4) | 0 | 10 (8.4) | 37 (31.1) | 5 (4.2) | 1 (0.8) | 26 (21.8) | 16 (13.4) | 2 (1.7) | 0 | 17 (14.3) | 119 | ||
| Total | 1 (0.4) | 14 (5.1) | 1 (0.4) | 34 (12.4) | 115 (42.0) | 7 (2.6) | 1 (0.4) | 34 (12.4) | 45 (16.4) | 2 (0.7) | 3 (1.1) | 17 (6.2) | 274 | ||
| Cefotaxime | |||||||||||||||
| 1994-1998 | 0 | 4 (28.6) | 6 (42.9) | 0 | 4 (28.6) | 14 | |||||||||
| 1999-2001 | 1 (7.1) | 4 (28.6) | 9 (64.3) | 0 | 0 | 14 | |||||||||
| 2002-2004 | 0 | 0 | 3 (75) | 1 (25) | 0 | 4 | |||||||||
| Total | 1 (3.1) | 8 (25) | 18 (56.3) | 1 (3.1) | 4 (12.5) | 32 | |||||||||
| Ceftriaxone | |||||||||||||||
| 1994-1998 | 0 | 3 (30) | 3 (30) | 1 (10) | 3 (30) | 10 | |||||||||
| 1999-2001 | 1 (7.7) | 4 (30.8) | 8 (61.5) | 0 | 0 | 13 | |||||||||
| 2002-2004 | 0 | 0 | 3 (75) | 1 (25) | 0 | 4 | |||||||||
| Total | 1 (3.7) | 7 (25.9) | 14 (51.9) | 2 (7.4) | 3 (11.1) | 27 | |||||||||
| Erythromycin | |||||||||||||||
| 1994-1998 | 0 | 0 | 7 (36.8) | 0 | 1 (5.3) | 6 (31.6) | 1 (5.3) | 0 | 2 (10.5) | 1 (5.3) | 0 | 0 | 1 (5.3) | 0 | 19 |
| 1999-2001 | 0 | 2 (2.9) | 20 (29.4) | 2 (2.9) | 3 (4.4) | 21 (30.9) | 3 (4.4) | 0 | 12 (17.6) | 3 (4.4) | 0 | 1 (1.5) | 1 (1.5) | 0 | 68 |
| 2002-2004 | 1 (1.0) | 0 | 10 (9.6) | 0 | 3 (2.9) | 21 (20.2) | 5 (4.8) | 1 (1.0) | 28 (26.9) | 2 (1.9) | 2 (1.9) | 4 (3.8) | 1 (1.0) | 26 (25.0) | 104 |
| Total | 1 (0.5) | 2 (1.0) | 37 (19.4) | 2 (1.0) | 7 (3.7) | 48 (25.1) | 9 (3.1) | 1 (0.5) | 42 (22.0) | 6 (3.1) | 2 (1.0) | 5 (2.6) | 3 (1.6) | 26 (13.6) | 191 |
| Clindamycin | |||||||||||||||
| 1994-1998 | 0 | 7 (53.8) | 0 | 0 | 1 (7.7) | 1 (7.7) | 0 | 2 (15.4) | 1 (7.7) | 0 | 0 | 1 (7.7) | 0 | 13 | |
| 1999-2001 | 2 (3.8) | 17 (32.7) | 1 (1.9) | 0 | 14 (26.9) | 2 (3.8) | 0 | 12 (23.1) | 3 (5.8) | 0 | 1 (1.9) | 0 (0.0) | 0 | 52 | |
| 2002-2004 | 0 | 9 (15.3) | 0 | 2 (3.4) | 4 (6.8) | 5 (8.5) | 1 (1.7) | 17 (28.8) | 2 (3.4) | 2 (3.4) | 4 (6.8) | 1 (1.7) | 12 (20.3) | 59 | |
| Total | 2 (1.6) | 33 (26.6) | 1 (1.8) | 2 (1.6) | 19 (15.3) | 8 (6.5) | 1 (0.8) | 31 (25.0) | 6 (4.8) | 2 (1.6) | 5 (4.0) | 2 (1.6) | 12 (9.7) | 124 | |
| Ciprofloxacin | |||||||||||||||
| 1994-1998 | 0 | 0 | 0 | 0 | 1 (100) | 0 | 1 | ||||||||
| 1999-2001 | 1 (33.3) | 0 | 2 (66.7) | 0 | 0 (33.3) | 0 | 3 | ||||||||
| 2002-2004 | 1 (9.1) | 1 (9.1) | 2 (18.2) | 1 (9.1) | 1 (9.1) | 5 (45.5) | 11 | ||||||||
| Total | 2 (13.3) | 1 (6.7) | 4 (26.7) | 1 (6.7) | 2 (13.3) | 5 (33.3) | 15 | ||||||||
a
Includes serogroups/types 4 (n = 1), 8 (n = 1), 10 (n = 1), 11 (n = 1); 22 (n = 1), and 34 (n = 1).
b
Not determined.