TABLE 1.
Susceptibility of C. neoformans B3501 biofilms to 213Bi- and 188Re-labeled MAbsa
| Antibody (radioactivity level [μCi]) | % Metabolic activity
|
|
|---|---|---|
| B3501 biofilm | B3501 planktonic cells | |
| 213Bi-18B7 (15) | 96 (5) | 75 (0.3) |
| 213Bi-18B7 (30) | 47 (5) | 31 (1.5) |
| 213Bi-MOPC21 (15) | 99 (0.8) | 94 (0.3) |
| 213Bi-MOPC21 (30) | 100 (2) | 94 (0.6) |
| 213Bi-13F1 (15) | 100 (1) | 86 (2) |
| 213Bi-13F1 (30) | 98 (1) | 34 (1) |
| 188Re-18B7 (200) | 99 (9) | 74 (1) |
| 188Re-18B7 (400) | 99 (2) | 17 (6) |
a
The metabolic activity of age-matched biofilms and planktonic cells was measured using a XTT reduction assay. The values represent the averages of three XTT measurements, and standard deviations are given in parentheses.