TABLE 6.
Selection frequencies of H. influenzae and M. catarrhalis strains by single-step methodology
| Strain | Drug | Frequency at MIC:
|
||||
|---|---|---|---|---|---|---|
| 2× MIC | 4× MIC | 8× MIC | ||||
| H. influenzae |
|
|||||
| HI 92 [BLPACR] | Ceftobiprole | <2.2 × 10−10 | <2.2 × 10−10
|
<2.2 × 10−10 | ||
| Amox-clava |
|
|||||
| Moxifloxacin | <3.3 × 10−10 | <3.3 × 10−10
|
<3.3 × 10−10 | |||
| Azithromycin | ∼2.7 × 10−10 | <2.7 × 10−10
|
<2.7 × 10−10 | |||
| Ceftriaxone | <1.2 × 10−10 | <1.2 × 10−10
|
<1.2 × 10−10 | |||
| Telithromycin | ∼1.3 × 10−8 | <2.5 × 10−10
|
<2.5 × 10−10 | |||
| 112-048 [Bla+] | Ceftobiprole | <1.3 × 10−10 | <1.3 × 10−10
|
<1.3 × 10−10 | ||
| Amox-clav | <1.0 × 10−10 | <1.0 × 10−10
|
<1.0 × 10−10 | |||
| Moxifloxacin | ∼2.0 × 10−8 | ∼5.7 × 10−9
|
<1.6 × 10−10 | |||
| Azithromycin | ∼2.6 × 10−10 | ∼1.3 × 10−10
|
<1.3 × 10−10 | |||
| Ceftriaxone | ∼1.0 × 10−8 | >1.0 × 10−9
|
<1.0 × 10−10 | |||
| Telithromycin | ∼2.5 × 10−9 | ∼2.0 × 10−10
|
<2.0 × 10−10 | |||
| 621-049 [Bla+] | Ceftobiprole | <2.0 × 10−10 | <2.0 × 10−10
|
<2.0 × 10−10 | ||
| Amox-clav | <1.0 × 10−10 | <1.0 × 10−10
|
<1.0 × 10−10 | |||
| Moxifloxacin | ∼1.0 × 10−8 | ∼1.0 × 10−10
|
<1.0 × 10−10 | |||
| Azithromycin | ∼1.5 × 10−9 | <2.8 × 10−10
|
<2.8 × 10−10 | |||
| Ceftriaxone | <2.9 × 10−10 | <2.9 × 10−10
|
<2.9 × 10−10 | |||
| Telithromycin | ∼8.0 × 10−10 | <4.0 × 10−10
|
<4.0 × 10−10 | |||
| 153-004 [Bla+] | Ceftobiprole | <3.1 × 10−10 | <3.1 × 10−10
|
<3.1 × 10−10 | ||
| Amox-clav | <1.0 × 10−10 | <1.0 × 10−10
|
<1.0 × 10−10 | |||
| Moxifloxacin | ∼3.3 × 10−8 | ∼6.7 × 10−9
|
∼3.3 × 10−9 | |||
| Azithromycin | ∼1.3 × 10−8 | <1.9 × 10−10
|
<1.9 × 10−10 | |||
| Ceftriaxone | <8.3 × 10−11 | <8.3 × 10−11
|
<8.3 × 10−11 | |||
| Telithromycin | ∼8.0 × 10−10 | <4.0 × 10−10
|
<4.0 × 10−10 | |||
| 110-019 [Bla+] | Ceftobiprole | <5.0 × 10−10 | <5.0 × 10−10
|
<5.0 × 10−10 | ||
| Amox-clav | <2.9 × 10−10 | <2.9 × 10−10
|
<2.9 × 10−10 | |||
| Moxifloxacin | <4.0 × 10−10 | <4.0 × 10−10
|
<4.0 × 10−10 | |||
| Azithromycin | ∼1.5 × 10−9 | <5.0 × 10−10
|
<5.0 × 10−10 | |||
| Ceftriaxone | <4.0 × 10−10 | <4.0 × 10−10
|
<4.0 × 10−10 | |||
| Telithromycin | ∼3.8 × 10−10 | <3.8 × 10−10
|
<3.8 × 10−10 | |||
| HI 30 [Bla+] | Ceftobiprole | <3.3 × 10−10 | <3.3 × 10−10
|
<3.3 × 10−10 | ||
| Amox-clav | <3.3 × 10−10 | <3.3 × 10−10
|
<3.3 × 10−10 | |||
| Moxifloxacin | >2.6 × 10−10 | <2.6 × 10−10
|
<2.6 × 10−10 | |||
| Azithromycin | ∼6.7 × 10−10 | <3.3 × 10−10
|
<3.3 × 10−10 | |||
| Ceftriaxone | <4.0 × 10−10 | <4.0 × 10−10
|
<4.0 × 10−10 | |||
| Telithromycin | ∼2.2 × 10−9 | ∼3.3 × 10−10
|
<3.3 × 10−10 | |||
| 153-008 [Bla−] | Ceftobiprole | <3.3 × 10−10 | <3.3 × 10−10
|
<3.3 × 10−10 | ||
| Amox-clav | ∼2.1 × 10−7 | <5.0 × 10−10
|
<5.0 × 10−10 | |||
| Moxifloxacin | ∼1.7 × 10−8 | <4.2 × 10−10
|
<4.2 × 10−10 | |||
| Azithromycin | ∼1.5 × 10−9 | <3.0 × 10−10
|
<3.0 × 10−10 | |||
| Ceftriaxone | <8.3 × 10−10 | <8.3 × 10−10
|
<8.3 × 10−10 | |||
| Telithromycin | <3.8 × 10−10 | <3.8 × 10−10
|
<3.8 × 10−10 | |||
| 110-061 [BLNAR] | Ceftobiprole | <3.7 × 10−10 | <3.7 × 10−10
|
<3.7 × 10−10 | ||
| Amox-clav | <5.0 × 10−10 | <5.0 × 10−10
|
<5.0 × 10−10 | |||
| Moxifloxacin | <3.2 × 10−10 | <3.2 × 10−10
|
<3.2 × 10−10 | |||
| Azithromycin | ∼3.3 × 10−10 | <3.3 × 10−10
|
<3.3 × 10−10 | |||
| Ceftriaxone | ∼7.5 × 10−7 | <5.0 × 10−10
|
<5.0 × 10−10 | |||
| Telithromycin | ∼5.6 × 10−9 | <3.7 × 10−10
|
<3.7 × 10−10 | |||
| M. catarrhalis |
|
|||||
| 36 [Bla+] | Ceftobiprole | <1.3 × 10−11 | <1.3 × 10−11
|
<1.3 × 10−11 | ||
| Amox-clav | <3.6 × 10−10 | <3.6 × 10−10
|
<3.6 × 10−10 | |||
| Moxifloxacin | ∼1.4 × 10−9 | <2.5 × 10−11
|
<2.5 × 10−11 | |||
| Azithromycin | <2.9 × 10−10 | <2.9 × 10−10
|
<2.9 × 10−10 | |||
| Ceftriaxone | <6.7 × 10−10 | <6.7 × 10−10
|
<6.7 × 10−10 | |||
| Telithromycin | ∼3.4 × 10−10 | ∼1.1 × 10−10
|
∼2.3 × 10−10 | |||
| 46 [Bla+] | Ceftobiprole | <4.3 × 10−11 | <4.3 × 10−11
|
<4.3 × 10−11 | ||
| Amox-clav | >3.6 × 10−6 | >3.6 × 10−7
|
>3.6 × 10−7 | |||
| Moxifloxacin | ∼1.6 × 10−9 | <2.7 × 10−10
|
<2.7 × 10−10 | |||
| Azithromycin | ∼2.0 × 10−9 | ∼2.0 × 10−10
|
∼2.0 × 10−10 | |||
| Ceftriaxone | >2.3 × 10−9 | >2.3 × 10−8
|
<2.3 × 10−10 | |||
| Telithromycin | <1.0 × 10−10 | <1.0 × 10−10 | <1.0 × 10−10 | |||
a
H. influenzae HI 92 is resistant to amoxicillin-clavulanate (Amox-clav) and therefore was not tested with this drug.