TABLE 6.
Strain | Drug | Frequency at MIC:
|
||||
---|---|---|---|---|---|---|
2× MIC | 4× MIC | 8× MIC | ||||
H. influenzae |
|
|||||
HI 92 [BLPACR] | Ceftobiprole | <2.2 × 10−10 | <2.2 × 10−10
|
<2.2 × 10−10 | ||
Amox-clava |
|
|||||
Moxifloxacin | <3.3 × 10−10 | <3.3 × 10−10
|
<3.3 × 10−10 | |||
Azithromycin | ∼2.7 × 10−10 | <2.7 × 10−10
|
<2.7 × 10−10 | |||
Ceftriaxone | <1.2 × 10−10 | <1.2 × 10−10
|
<1.2 × 10−10 | |||
Telithromycin | ∼1.3 × 10−8 | <2.5 × 10−10
|
<2.5 × 10−10 | |||
112-048 [Bla+] | Ceftobiprole | <1.3 × 10−10 | <1.3 × 10−10
|
<1.3 × 10−10 | ||
Amox-clav | <1.0 × 10−10 | <1.0 × 10−10
|
<1.0 × 10−10 | |||
Moxifloxacin | ∼2.0 × 10−8 | ∼5.7 × 10−9
|
<1.6 × 10−10 | |||
Azithromycin | ∼2.6 × 10−10 | ∼1.3 × 10−10
|
<1.3 × 10−10 | |||
Ceftriaxone | ∼1.0 × 10−8 | >1.0 × 10−9
|
<1.0 × 10−10 | |||
Telithromycin | ∼2.5 × 10−9 | ∼2.0 × 10−10
|
<2.0 × 10−10 | |||
621-049 [Bla+] | Ceftobiprole | <2.0 × 10−10 | <2.0 × 10−10
|
<2.0 × 10−10 | ||
Amox-clav | <1.0 × 10−10 | <1.0 × 10−10
|
<1.0 × 10−10 | |||
Moxifloxacin | ∼1.0 × 10−8 | ∼1.0 × 10−10
|
<1.0 × 10−10 | |||
Azithromycin | ∼1.5 × 10−9 | <2.8 × 10−10
|
<2.8 × 10−10 | |||
Ceftriaxone | <2.9 × 10−10 | <2.9 × 10−10
|
<2.9 × 10−10 | |||
Telithromycin | ∼8.0 × 10−10 | <4.0 × 10−10
|
<4.0 × 10−10 | |||
153-004 [Bla+] | Ceftobiprole | <3.1 × 10−10 | <3.1 × 10−10
|
<3.1 × 10−10 | ||
Amox-clav | <1.0 × 10−10 | <1.0 × 10−10
|
<1.0 × 10−10 | |||
Moxifloxacin | ∼3.3 × 10−8 | ∼6.7 × 10−9
|
∼3.3 × 10−9 | |||
Azithromycin | ∼1.3 × 10−8 | <1.9 × 10−10
|
<1.9 × 10−10 | |||
Ceftriaxone | <8.3 × 10−11 | <8.3 × 10−11
|
<8.3 × 10−11 | |||
Telithromycin | ∼8.0 × 10−10 | <4.0 × 10−10
|
<4.0 × 10−10 | |||
110-019 [Bla+] | Ceftobiprole | <5.0 × 10−10 | <5.0 × 10−10
|
<5.0 × 10−10 | ||
Amox-clav | <2.9 × 10−10 | <2.9 × 10−10
|
<2.9 × 10−10 | |||
Moxifloxacin | <4.0 × 10−10 | <4.0 × 10−10
|
<4.0 × 10−10 | |||
Azithromycin | ∼1.5 × 10−9 | <5.0 × 10−10
|
<5.0 × 10−10 | |||
Ceftriaxone | <4.0 × 10−10 | <4.0 × 10−10
|
<4.0 × 10−10 | |||
Telithromycin | ∼3.8 × 10−10 | <3.8 × 10−10
|
<3.8 × 10−10 | |||
HI 30 [Bla+] | Ceftobiprole | <3.3 × 10−10 | <3.3 × 10−10
|
<3.3 × 10−10 | ||
Amox-clav | <3.3 × 10−10 | <3.3 × 10−10
|
<3.3 × 10−10 | |||
Moxifloxacin | >2.6 × 10−10 | <2.6 × 10−10
|
<2.6 × 10−10 | |||
Azithromycin | ∼6.7 × 10−10 | <3.3 × 10−10
|
<3.3 × 10−10 | |||
Ceftriaxone | <4.0 × 10−10 | <4.0 × 10−10
|
<4.0 × 10−10 | |||
Telithromycin | ∼2.2 × 10−9 | ∼3.3 × 10−10
|
<3.3 × 10−10 | |||
153-008 [Bla−] | Ceftobiprole | <3.3 × 10−10 | <3.3 × 10−10
|
<3.3 × 10−10 | ||
Amox-clav | ∼2.1 × 10−7 | <5.0 × 10−10
|
<5.0 × 10−10 | |||
Moxifloxacin | ∼1.7 × 10−8 | <4.2 × 10−10
|
<4.2 × 10−10 | |||
Azithromycin | ∼1.5 × 10−9 | <3.0 × 10−10
|
<3.0 × 10−10 | |||
Ceftriaxone | <8.3 × 10−10 | <8.3 × 10−10
|
<8.3 × 10−10 | |||
Telithromycin | <3.8 × 10−10 | <3.8 × 10−10
|
<3.8 × 10−10 | |||
110-061 [BLNAR] | Ceftobiprole | <3.7 × 10−10 | <3.7 × 10−10
|
<3.7 × 10−10 | ||
Amox-clav | <5.0 × 10−10 | <5.0 × 10−10
|
<5.0 × 10−10 | |||
Moxifloxacin | <3.2 × 10−10 | <3.2 × 10−10
|
<3.2 × 10−10 | |||
Azithromycin | ∼3.3 × 10−10 | <3.3 × 10−10
|
<3.3 × 10−10 | |||
Ceftriaxone | ∼7.5 × 10−7 | <5.0 × 10−10
|
<5.0 × 10−10 | |||
Telithromycin | ∼5.6 × 10−9 | <3.7 × 10−10
|
<3.7 × 10−10 | |||
M. catarrhalis |
|
|||||
36 [Bla+] | Ceftobiprole | <1.3 × 10−11 | <1.3 × 10−11
|
<1.3 × 10−11 | ||
Amox-clav | <3.6 × 10−10 | <3.6 × 10−10
|
<3.6 × 10−10 | |||
Moxifloxacin | ∼1.4 × 10−9 | <2.5 × 10−11
|
<2.5 × 10−11 | |||
Azithromycin | <2.9 × 10−10 | <2.9 × 10−10
|
<2.9 × 10−10 | |||
Ceftriaxone | <6.7 × 10−10 | <6.7 × 10−10
|
<6.7 × 10−10 | |||
Telithromycin | ∼3.4 × 10−10 | ∼1.1 × 10−10
|
∼2.3 × 10−10 | |||
46 [Bla+] | Ceftobiprole | <4.3 × 10−11 | <4.3 × 10−11
|
<4.3 × 10−11 | ||
Amox-clav | >3.6 × 10−6 | >3.6 × 10−7
|
>3.6 × 10−7 | |||
Moxifloxacin | ∼1.6 × 10−9 | <2.7 × 10−10
|
<2.7 × 10−10 | |||
Azithromycin | ∼2.0 × 10−9 | ∼2.0 × 10−10
|
∼2.0 × 10−10 | |||
Ceftriaxone | >2.3 × 10−9 | >2.3 × 10−8
|
<2.3 × 10−10 | |||
Telithromycin | <1.0 × 10−10 | <1.0 × 10−10 | <1.0 × 10−10 |
H. influenzae HI 92 is resistant to amoxicillin-clavulanate (Amox-clav) and therefore was not tested with this drug.