TABLE 1.
Characteristics of the parental and derived mutant strains of S. aureus included in this studye
| Parental or mutant (M) strain | MIC (μg/ml) (+ reserpine)a of: |
Mutation |
||||||
|---|---|---|---|---|---|---|---|---|
| NOR | CIP | GAT | MXF | EtBr | GrlA | GyrA | flqB | |
| ATCC 25923 | 2 (1) | 0.5 (0.2) | 0.1 (0.1) | 0.05 (0.05) | 8 (4) | —c | — | — |
| SA-1 | 16 (2) | 16 (0.5) | 0.5 (0.1) | 0.1 (0.05) | 32 (8) | — | — | T→Cd |
| MSA-1 | 2,048 (128) | 256 (64) | 16 (4) | 8 (2) | 32 (8) | Ser80Phe | Ser84Leu | T→Cd |
| Sa2102b | 16 (16) | 2 (2) | 0.2 (0.2) | 0.2 (0.1) | 4 (4) | Ser80Tyr | — | — |
| MSa2102b | 256 (128) | 64 (64) | 8 (4) | 4 (4) | 4 (4) | Ser80Tyr | Ser84Leu | — |
| Sa2667 | 32 (32) | 4 (4) | 0.5 (0.5) | 0.5 (0.5) | 8 (4) | Ser80Phe | — | — |
| MSa2667 | 2,048 (256) | 256 (64) | 8 (4) | 2 (1) | 128 (8) | Ser80Phe | Ser84Ala | — |
| Sa2669b | 64 (32) | 16 (8) | 1 (1) | 0.5 (0.5) | 4 (2) | Ser80Phe | Ser84Ala | — |
| MSa2669b | 128 (128) | 32 (32) | 4 (4) | 2 (2) | 4 (4) | Ser80Phe | Ser84Val | — |
a
MICs indicated in parentheses have been determined in presence of reserpine at 128 μg/ml.
b
Methicillin-resistant S. aureus.
c
—, no mutation.
d
Eighty-eight bases upstream from the ATG initiation codon of the norA gene.
e
Abbreviations: NOR, norfloxacin; CIP, ciprofloxacin; GAT, gatifloxacin; MXF, moxifloxacin; EtBr, ethidium bromide.