TABLE 3.
Mean pharmacokinetic parameters (n = 2) for the peripheral (PCp) compartment after simulation of a once-daily 1-h infusion of 400 mg of gatifloxacin over 48 h and the corresponding human reference data
| Parameter (unit) | Dosing interval |
Human dataa |
||
|---|---|---|---|---|
| 0-24 h | 24-48 h | Female (n = 12) | Male (n = 12) | |
| Cmax (μg/ml) | 5.36 | 5.80 | 6.07 ± 0.77 | 5.47 ± 0.98 |
| Cres (μg/ml) | 0.33 | 0.34 | ||
| t1/2α (h) | 0.40 | 0.49 | ||
| t1/2β (h) | 8.68 | 7.80 | 6.24 ± 0.85 | 7.66 ± 0.83 |
| AUC0-24 (h × μg/ml) | 30.6 | 35 | ||
| AUC0-∞ (h × μg/ml) | 34.7 | 38.9 | 37.4 ± 5.61 | 34.1 ± 8.50 |
| MRT (h) | 11.1 | 10.3 | 8.10 ± 1.28 | 9.41 ± 1.34 |
| CL (liters/h) | 11.5 | 10.3 | 10.9 ± 1.74 | 12.3 ± 2.44 |
| CL (ml/min) | 192 | 171 | 182 ± 28.9 | 205 ± 40.8 |
| Vβ (liters) | 144 | 116 | 97.1 ± 10.7 | 133 ± 18.6 |
| Vss (liters) | 125 | 104 | 87.1 ± 9.33 | 113 ± 17.3 |
| Correlation coefficient | 0.99 | 0.99 | ||
a
Human data are from LaCreta et al. (24).