TABLE 2.

BCV pharmacokinetic parameters following single-dose administration of BCV alone

BCV dose (mg)	No. of subjects receiving a dose	Median Tmax (range) (h)	Geometric mean (95% CI)
			AUC0-∞ (ng · h/ml)	Cmax (ng/ml)	t1/2 (h)
25	6	0.50 (0.28-1.00)	2.51a	1.71 (1.18, 2.49)	0.300a
50	6	0.50 (0.47-0.73)	4.90b (2.40, 10.0)	3.32 (2.03, 5.42)	0.677b (0.416, 1.10)
150	9	0.77 (0.48-2.00)	21.5 (11.2, 41.1)	12.7 (7.65, 21.0)	0.993 (0.566, 1.74)
300	13	1.53 (0.98-4.02)	105 (52.7, 210)	29.9 (16.3, 54.8)	2.63 (1.85, 3.74)
450	10	2.48 (0.73-3.97)	203 (116, 354)	41.3 (20.8, 82.2)	6.41 (3.38, 12.2)
800	11	1.48 (0.58-3.97)	396 (242, 647)	73.7 (47.2, 115)	12.3 (7.72, 19.4)

^aOne subject.

^bFive subjects.