TABLE 6.
Analysis of cases with negative HCII but positive HPV Blot results for the 26 non-HCII HPV typesa
Case | Cytological finding | HPV type(s) | HPV type determined by:
|
Pathology | |
---|---|---|---|---|---|
Direct sequencing | Other verification method | ||||
13 | Negative | CP8304 | CP8304 | NA | |
36 | Negative | CP8304, 37, 53 | CP8304 | NA | |
57 | Negative | MM8 | MM8 | NA | |
77 | Negative | 70 | 70 | NA | |
84 | Normal | 33, 61, 70 | 61 | 61b | NA |
134 | Negative | MM8 | MM8 | NA | |
164 | ASCUS | CP8061 | CP8061 | CP8061b | Negative |
173 | Negative | 26 | 26 | NA | |
179 | ASCUS | 77 | NAc | 77b | NA |
191 | ASCUS | 53 | 53 | NA | |
301d | LSIL | MM8, 53 | NA | 53b | NA |
302 | Negative | 53 | NA | 53b | NA |
327 | ASCUS | 42 | 42 | NA | |
329 | Negative | 69 | NA | 69b | NA |
335 | ASCUS | 53 | 53 | NA |
n = 15. The 26 non-HCII HPV types were HPV-6, -11, -26, -32, -37, -42, -43, -44, -53, -54, -55, -61, -62, -66, -67, -69, -70, -72, -74, -82, -CP8061, -CP8304, -L1AE5, -MM4, -MM7, -MM8. New carcinogenic and probably carcinogenic types are shown in boldface type.
Paraffin-embedded cervical biopsy tissue for HPV genotyping using HPV Blot.
NA, not applicable. The amount of PCR product was insufficient for direct sequencing.
Follow-up 6 months later showed that the sample was HCII positive and HPV Blot MM8 and 53 positive.