TABLE 1.
Rate constants (ka, kd) and dissociation constant (Kd) of IgG form of Abs with DTD and DT assayed by the BIAcore instrument
Clone | Anti-DTD
|
Anti-DT
|
||||
---|---|---|---|---|---|---|
ka (104 M−1 s−1) | kd (10−4 s−1) | Kd (10−9 M) | ka (104 M−1 s−1) | kd (10−4 s−1) | Kd (10−9 M) | |
DTD4 | 4.14 | 8.70 | 21.2 | 10.6 | 3.19 | 3.01 |
DTD8 | 4.99 | 3.82 | 7.66 | 16.2 | 0.831 | 0.513 |
DTD10 | 8.89 | 3.76 | 4.22 | 8.52 | 0.243 | 0.285 |
DTD76 | 11.9 | 2.29 | 1.93 | 7.8 | 4.83 | 6.19 |