TABLE 1.
Growth of meningococcal strains in whole mouse blood from B6 and MyD88−/− mice
| Time postinfection (h) | Bacterial strain | Growth in mouse blood (CFU/ml)a
|
|
|---|---|---|---|
| B6 | MyD88−/− | ||
| 1 | FAM20b | 3.6 × 105 (4.5 × 104) | 3.0 × 105 (1.2 × 104) |
| lpxA mutantc | 1.1 × 105 (2.2 × 104) | 1.6 × 105 (5.1 × 104) | |
| 4 | FAM20b | 4.6 × 106 (1.4 × 105) | 3.6 × 106 (4.3 × 105) |
| lpxA mutantc | 3.6 × 105 (1.2 × 105) | 8.0 × 105 (1.4 × 105)* | |
a
Data are presented as mean (standard deviation). *, statistically significant difference (P < 0.05) in bacterial numbers compared to numbers in B6 mice observed using a Student's t test.
b
Original inoculum, 1.8 × 105 CFU/ml.
c
Original inoculum, 1.1 × 105 CFU/ml.