Figure 1.

Flow diagram. Abbreviations: RCT, randomized controlled trial; n, number of trials. * Parameter of interest: Reported effectiveness of the pharmaceutical, measured as change of intraocular pressure (Timolol, Latanoprost) or change in low-density lipoprotein cholesterol (Pravastatin, Atorvastatin). ** Dose of interest: In terms of comparability studies that did not use the pharmaceutical in the most common dosage were excluded, as well as studies that increased the individual dosage until a certain outcome was reached.