Table 4.
Manual curation of Gene Cluster #18 genes
| Protein description | Gene Sym Symbol | LocusLink ID | Function | Reference | |
| A | CD72 | Cd72 | 12517 | BCR coreceptor | 32–34 35 |
| dual specificity phosphatase 14 | Dusp14 | 56405 | lymphocyte signaling | 36 | |
| mitogen activated protein kinase kinase kinase kinase 1 | Map4k1 | 26411 | lymphocyte signaling | 37–39 | |
| mitogen activated protein kinase kinase 3 | Map2k3 | 26397 | lymphocyte signaling | 40, 41 | |
| serine/threonine kinase receptor associated protein | Strap | 20901 | TGFbeta signaling | 42 | |
| dishevelled associated activator of morphogenesis 1 | Daam1 | 208846 | Wnt signaling | 43 | |
| FK506 binding protein 1a | Fkbp1a | 14225 | BCR signaling/apoptosis | 44–46 | |
| nuclear factor of activated T-cells, cytoplasmic 2 interacting protein | Nfatc2ip | 18020 | BCR signaling/apoptosis | 44–46 | |
| sorting nexin 5 | Snx5 | 69178 | endocytosis | 47, 48 | |
| IQ motif containing GTPase activating protein 1 | Iqgap1 | 29875 | vesicle formation | 49, 50 | |
| amyotrophic lateral sclerosis 2 (juvenile) homolog (human) | Als2 | 74018 | endosome fusion/Rab GEF | 51, 52 | |
| RAB18, RAS family | Rab18 | 19330 | endocytosis/vesicle recycling | 53–56 56 | |
| RAB22, RAS family | Rab22a | 19334 | early endosome trafficking | 56, 57 | |
| Proton pump, subunit V0B (21 kDa) | Atp6v0b | 114143 | vesicle acidification | 58–60 | |
| Proton pump, subunit V1G1 (13 kDa) | Atp6v1g1 | 66290 | vesicle acidification | 58–60 | |
| Proton pump, subunit V1C1 (42 kDa) | Atp6v1c1 | 66335 | vesicle acidification | 58–60 | |
| similar to Proton pump, subunit V1F | 76610 | vesicle acidification | 58–60 | ||
| Proton pump accessory protein 2 | Atp6ap2 | 70495 | vesicle acidification | 61, 62 | |
| Chloride channel 7 | Clcn7 | 26373 | vesicle pH regulation | 63, 64 | |
| dystrobrevin binding protein 1 (dysbindin) | Dtnbp1 | 94245 | lysosome formation | 65 | |
| cystatin B | Cstb | 13014 | cathepsin protease inhibitor | 66–68 | |
| hexosaminidase A | Hexa | 15211 | hydrolase | 69–71 | |
| ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease) | Cln3 | 12752 | lysosome function | 72 | |
| HSP70 binding protein | Hspbp1 | 66245 | Ag processing/loading | 73 | |
| similar to HSPC135 | 66067 | chaperone (?), GTPase (?) | |||
| HSPC245 homolog | chaperone (?) | ||||
| N-ethylmaleimide sensitive fusion protein attachment protein alpha | Napa | 108124 | vesicle fusion | 74, 75 | |
| RAB9, RAS family | Rab9 | 56382 | vesicle tethering | 76, 77 | |
| activating transcription factor 1 | Atf1 | 11908 | MHC expression | 78 | |
| Sec61 alpha | Sec61a1 | 53421 | ER translocation | 79 | |
| signal sequence receptor, alpha | Ssr1 | 107513 | MHCII chaperone | 80 | |
| calmegin | Clgn | 12745 | MHC chaperone | 81, 82 | |
| similar to signal peptidase SPC22/23 | 76687 | secretory protein processing | 83 | ||
| vacuolar protein sorting 29 | Vps29 | 56433 | retrograde vesicle transport | 84, 85 | |
| reticulon 3 | Rtn3 | 20168 | exocytosis | 86, 87 | |
| tubulin, alpha 6 | Tuba6 | 22146 | cytoskeletal trafficking | 88, 89 | |
| CD63 | Cd63 | 12512 | MHCII coreceptor | 90–92 | |
| source of immunodominant MHC-associated peptides | Simp | 68292 | MHC peptide | 93 | |
| B | 24-dehydrocholesterol reductase | Dhcr24 | 74754 | Cholesterol biosynthesis | 94 |
| fatty acid binding protein 5, epidermal | Fabp5 | 16592 | Fatty acid intracellular transport | 95 | |
| phosphatidylethanolamine binding protein | Pbp | 23980 | Membrane lipid transport | 96 | |
| prostaglandin D2 synthase 2, hematopoietic | Ptgds2 | 54486 | |||
| peroxisome biogenesis factor 1 | Pex1 | 71382 | Peroxisomal protein tranport | 97 | |
| C | beclin 1 (coiled-coil, myosin-like BCL2-interacting protein) | Becn1 | 56208 | Tumor suppression | 98, 99 |
| caspase 4, apoptosis-related cysteine protease | Casp4 | 12363 | Apoptosis | 100–102 | |
| Cd27 binding protein (Hindu God of destruction) | Siva | 30954 | Apoptosis | 103, 104 | |
| D | polymyositis/scleroderma autoantigen 2 | Pmscl2 | 50912 | RNA processing autoantigen | 105 |
| Sjogren's syndrome/scleroderma autoantigen 1 homolog (human) | Sssca1 | 56390 | centromeric autoantigen | 106 | |
| amyotrophic lateral sclerosis 2 (juvenile) homolog (human) | Als2 | 74018 | endosome fusion/Rab GEF | 51, 52 |
Genes found in Gene Cluster #18 with functions related to (A) intracellular trafficking, BCR signaling, vesicle processing and function, and antigen processing and presentation, (C) apoptosis, and (D) B cell-related autoimmune disease. (B) Genes annotated with "transporter" activity whose roles are not yet known to be associated with intracellular trafficking.