Figure 10. The cell-permeable peptide TAT-Ser345 inhibits the basal and primed ROS production by neutrophils from patients with RA.

Neutrophils isolated from RA patients (5 × 10⁵) were incubated with a cell-permeable peptide corresponding to TAT-peptide-Ser345 sequence or with a scramble peptide for 30 minutes, then ROS production was measured with the luminol-amplified chemiluminescence technique in the absence (A) or presence (B) of fMLP (10^–7 M). Data are presented as mean ± SEM (n = 3). *P < 0.05.