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. 2006 May 5;7(6):622–627. doi: 10.1038/sj.embor.7400687

Figure 1.

Figure 1

RIP is required for the activation of JNK induced by the ER stress agents. (A) WT and RIP−/− cells were treated with 2 μM Tg and 15 μg/ml Tu. Cell extracts were used for JNK kinase assay and western blot. (B) Protein expression levels in WT, RIP−/− and RIP−/−(RIP) cells. (C) Reconstitution of ER stress agent-induced JNK activation in RIP−/−(RIP) cells. WT, RIP−/− and RIP−/−(RIP) cells were treated with Tg or Tu. Cell extracts were used for JNK kinase assay and western blot. ER, endoplasmic reticulum; JNK, Jun amino-terminal kinase; RIP, tumour necrosis factor receptor-interacting protein; Tg, thapsigargin; Tu, tunicamycin; WT, wild type. Numbers on the left are relative molecular masses.