Skip to main content
. 2006 Jun 14;397(Pt 1):1–14. doi: 10.1042/BJ20060175

Table 1. Cx mimetic peptides – structures and properties.

Name Cx numbers/sequence Protein domain Properties Reference(s)
Gap peptides
 Gap 26 43, 32, 26 64–76 EL1 Inhibits CxHc within minutes and gap junctions later [131,136]
VCYDKSFPISHVR
 Gap 27/43 43, 37, 32, 26 201–211 EL2 Inhibits CxHc within minutes and gap junctions later [131139]
(43Gap 27) SRPTEKTIFII
 Gap 27/40 40 201–221 EL2 Inhibits Cx40 gap junctions (effects on CxHc not investigated) [115,131]
(40Gap 27) SRPTEKNVFIV
 Gap 24 32 110–122 IL Inhibits Cx32Hc and not gap junctions [146]
GHGDPLHLEEVKC
L2 peptide 43 119–144 IL Influences gap junction channel gating [148]
Other peptides
 No name 43 180–195 EL2 Inhibits Cx43 gap junctions [205]
SLSAVYTCKRDPCPHE
 No name 40 177–192 EL2 Inhibits Cx40 gap junctions [205]
FLDTLHVCRRSPCPHP
 No name 32 52–63 EL1 Inhibits Cx32 gap junctions in hepatocytes [156]
ICNTLQPGCNSV
 No name 32 41–42 EL1 One of several peptides inhibiting gap junctions in oocytes [204]
ESVWGDEKSSFI