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Interaction of the B30.2 domain of human pyrin with caspase-1. (A) Human caspase-1 was cotransfected into PT67 cells with various N-terminal GST-fused pyrin-expressing constructs depicted in the schematic, as indicated. PYD, pyrin domain; B, B-box zinc finger domain; C-C, coiled-coil domain; R, B30.2 domain. Lysates were analyzed as in Fig. 2B. (B) Caspase-1 was cotransfected with GST vector (first lane) or GST-fused B30.2 domain of pyrin. Lysates were analyzed as in Fig. 2B.
