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. 2005 Dec 1;570(Pt 3):553–565. doi: 10.1113/jphysiol.2005.093781

Figure 8. Glycine rescues sleep deprivation-induced LTP impairment.

Figure 8

A, representative NMDA whole cell currents with and without 10 μm glycine from control (above) and sleep deprived rats (below). B, bar graph showing that glycine potentiation of NMDA currents is unaffected by sleep deprivation. C, graph showing addition of 10 μm glycine enhances LTP at Schaffer collateral synapses in slices from sleep deprived rats. D, graph reproduced with permission from McDermott et al. (2003) showing impairment of LTP after sleep deprivation. (©2003 by the Society for Neuroscience.) Graphs from C and D represent grouped data showing normalized fEPSP slope. LTP induction occurred at the 10 min time point. E, bar graph summarizing potentiation (mean ±s.e.m.) of fEPSP slope at 30 min post-tetanus for all treatment conditions. Control and SD data in the absence of glycine are from McDermott et al. (2003). *P < 0.05.