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. 2005 Nov 24;570(Pt 3):541–551. doi: 10.1113/jphysiol.2005.098715

Figure 2. Loss of NP gene or inhibition of NP abolished E-LTP and reduced theta-burst-induced LTP.

Figure 2

A, E-LTP induced by a single train of tetanus is impaired in NP-knockout mice. Representative waveforms of fEPSP slopes recorded before (1) or 60 min after (2) tetanization in NP-knockout (NP KO, •) and wild-type (○) mice are shown on the top. B and C, NP inhibitor, NP stop, significantly blocked theta-burst LTP and completely blocked E-LTP elicited by a single train of tetanus. NP stop (•) or saline (○) was applied intracerebroventricularly for 40 min before theta-burst stimuli (TBS) or tetanus. A stimulus was then applied after 15 min to the Schaffer collateral pathway. In each panel, representative waveforms of fEPSP slopes recorded before (1) or 90 min or 60 min after (2) TBS or tetanization in the presence of saline (Control) or NP stop are shown on the top. Horizontal bar denotes the period of delivery of saline or NP stop. Values are expressed as percentage of baseline. Scale bars, 2 mV and 10 ms. Symbols indicate the mean ±s.e.m.