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. Author manuscript; available in PMC: 2006 Jun 20.
Published in final edited form as: Circ Res. 2005 Oct 13;97(11):1190–1197. doi: 10.1161/01.RES.0000190634.60042.cb

Figure 2.

Figure 2

Effects of D-4F on vasodilation. (A) Line graph showing vasodilation from C57BL/6 mice, Ldlr −/− mice fed lab chow and Ldlr −/− mice fed WD for 6 weeks. vasodilation for C57BL/6 mice and Ldlr −/− mice fed lab chow are significantly different from vasodilation for Ldlr −/− mice fed WD. (B) Line graph showing time-dependent effects of D-4F on vasodilation in hypercholesterolemic Ldlr −/− mice. Vasodilation for Ldlr −/− mice fed WD is restored and improved in direct relation to the duration of D-4F treatments. (C) Line graph showing effects of D-4F on vasodilation in hypercholesterolemic mice with pre-existing disease. Two weeks of D-4F treatments increases vasodilation in vessels with pre-existing disease. (** = p<0.02, *** = p<0.01).