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Effects of D-4F on Vasodilation and Wall Thickness in Hypercholesterolemic Ldlr −/− /apoA-I −/− mice. (A) Line graph showing effects of D-4F on vasodilation in Ldlr −/− /apoA-I −/− mice fed WD and treated with D-4F (1mg/kg/d) for 6–8 weeks. Vasodilation for Ldlr −/− /apoA-I −/− mice fed WD is increased in mice treated with D-4F (n=7–8, ** = p<0.02). (B) Bar graph showing D-4F has no effect on wall thickness in the vessels in the Ldlr −/− /apoA-I −/− mice (n=7–8).
