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. Author manuscript; available in PMC: 2006 Jun 20.
Published in final edited form as: J Med Chem Biol Radiol Def. 2005 Jul 1;3:nihms5095. doi: 10.1901/jaba.2005.3-nihms5095

Figure 9.

Figure 9

Residence time of purified human BChE in monkeys Two monkeys were injected with 16.8 ml and 19.5 ml of purified human BChE iv to give a dose of 4 mg/kg. The BChE solution had a concentration of 3 mg/ml. Blood was withdrawn at 10, 30, 60, 120 min, 6 h, 12 h, 24 h, 2 days, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, and 14 days and assayed in triplicate for BChE activity. The symbols are the data, the line is the fit to the double exponential equation Ct = Ae(−k1t) + Be(−k2t). The half-life, calculated from the first order rate constant was 5.5 h for the fast phase and 66.4 h for the slow phase. The mean residence time was 93.2 h.