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Equilibria defining the pKa values observed for Cbl derivatives. Shown are the equilibria for free Cbl derivatives, in which X is the upper axial ligand [HOH for aqCbl, CH3 for MeCbl, or an electron for cob(II)alamin]. The first step is the dissociation of the dimethylbenzimidazole ribonucleotide from the cobalt, and the second step is the protonation of the dissociated dimethylbenzimidazole ribonucleotide.
