Fig. 6.

Schematic representation of the entropic barrier. (left) The barrier is formed by the brush-like conformations of the cNup153 molecules that are tethered to the nanodot surface. The gray shaded area emphasizes the stochastic nature of the molecules over large time scales (approximately microseconds). A non-NLS cargo (blue, hatched) is repelled once it is within the near-field of the cNup153 molecules. (right) A receptor-bound cargo (blue, hatched with black dashes) is “trapped” because of attractive interactions that occur between the transport receptor and several FG sites (indicated by red dotted circles).