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Effects of ΔE mutation on proliferation, suppressor function, and IL2 secretion. The ΔE mutation in Foxp3 leads to loss of suppressor function of Foxp3-transduced CD4 cells cultured alone (A) or with purified CD4+CD25− T cells (B). (C) IL-2 secretion was measured in transduced CD4 cells that were cultured alone.
