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. 2006 Jun 12;103(25):9685–9690. doi: 10.1073/pnas.0600554103

Fig. 4.

Fig. 4.

Relative potency of tetracycline derivatives as neuroprotectants and PARP-1 inhibitors. (A) Neuron death evaluated 24 h after 30-min incubations with MNNG (75 μM) alone or in combination with the designated concentrations minocycline (Mino), doxycycline (Doxy), demeclocycline (Demeclo), chlortetracyceline (Chlortet), or the established PARP inhibitor DPQ. (B) Activity of isolated, recombinant PARP-1 in the presence of the same agents used in A. (C) Scatter plot showing the relative potencies of the tetracycline derivatives as neuroprotectants and PARP-1 inhibitors. Data are means ± SEM.