Palmitoylation of apoB-29 is required for
localization to a subcompartment of the ER. Colocalization studies of
various apoBs with the ER marker protein PDI. Various human apoBs were
detected with the 1D1 mouse mAb and are shown in red with the use of
anti-mouse IgG-TR–conjugated secondary antibody (left panels). PDI was
detected with the use of the rabbit polyclonal anti-PDI antibody and is
shown in green with the use of anti-rabbit IgG-FITC–conjugated
secondary antibody (middle panels). The merged images are shown in the
right panels. Staining of McArdle-RH7777 cells stably expressing WT
apoB-29, Cys1085Ser apoB-29, or apoB-18 and nontransfected
McArdle-RH7777 cells is shown and identified as follows: MH-WT apoB-29,
MH-apoB-29(Cys1085Ser), MH-apoB-18, and MH, respectively.