Table 2.
Odds Ratios for BE and dysplastic BE associated with history of acid reflux
| Controls | BE | BE with dysplasia | |||||
|---|---|---|---|---|---|---|---|
| Exposure | N=261 | N=117 | Crude OR (95% CI)* | Adjusted OR (95% CI)† | N=50 | Crude OR (95% CI)* | Adjusted OR (95% CI)† |
| Acid reflux ever | |||||||
| No | 50% | 16% | 1.0 | 1.0 | 6% | 1.0 | 1.0 |
| Yes | 50% | 84% | 4.9 (2.8-8.6) | 4.8 (2.7-8.5) | 94% | 15.3 (4.6-50.5) | 16.9 (5.0-57.2) |
| Acid reflux past year | |||||||
| Never | 62% | 21% | 1.0 | 1.0 | 17% | 1.0 | 1.0 |
| Monthly | 35% | 36% | 3.0 (1.7 – 5.4) | 2.9 (1.6 – 5.4) | 35% | 3.6 (1.5-8.7) | 4.1 (1.6-10.5) |
| Weekly | 3% | 43% | 32.3 (13.4 – 78.1) | 29.7 (12.2 – 72.6) | 48% | 51.5 (16.9-157) | 59.7 (18.5-193) |
| Acid reflux age 10-19 yrs | |||||||
| Never | 94% | 91% | 1.0 | 1.0 | 86% | 1.0 | 1.0 |
| Monthly | 5% | 7% | 0.8 (0.3-2.3) | 0.8 (0.3-2.3) | 7% | 1.2 (0.3-4.6) | 1.2 (0.3-4.7) |
| Weekly | 1% | 2% | 0.9 (0.1-7.0) | 1.7 (0.2-16.8) | 7% | 6.7 (1.2-38.4) | 13.2 (1.8-98.5) |
| Acid reflux age 20-29 yrs‡ | |||||||
| Never | 87% | 69% | 1.0 | 1.0 | 67% | 1.0 | 1.0 |
| Monthly | 11% | 20% | 1.7 (0.9-3.4) | 1.7 (0.9-3.4) | 17% | 1.9 (0.8-4.7) | 2.1 (0.8-5.3) |
| Weekly | 2% | 11% | 5.0 (1.5-17.4) | 6.7 (1.7-26.6) | 15% | 15.4 (3.8-70.0) | 24.5 (4.8-124) |
| Acid reflux age 30-49 yrs§ | |||||||
| Never | 75% | 44% | 1.0 | 1.0 | 31% | 1.0 | 1.0 |
| Monthly | 22% | 32% | 1.8 (1.0-3.2) | 1.7 (0.9-3.0) | 40% | 3.5 (1.6-7.5) | 3.6 (1.6-8.1) |
| Weekly | 3% | 24% | 8.7 (3.6-21.4) | 9.9 (3.8-25.5) | 29% | 21.2 (7.2-62.7) | 27.3 (8.5-87.4) |
| Acid reflux age 50-79 yrs∥ | |||||||
| Never | 56% | 25% | 1.0 | 1.0 | 5% | 1.0 | 1.0 |
| Monthly | 40% | 45% | 2.3 (1.2-4.6) | 2.2 (1.1-4.4) | 55% | 14.3 (3.2-62.9) | 14.8 (3.3-66.5) |
| Weekly | 5% | 31% | 12.5 (4.9-31.9) | 13.5 (5.0-37.0) | 40% | 89.7 (17.6-457) | 96.7 (18.2-514) |
| Acid reflux for current age group | |||||||
| Never | 55% | 21% | 1.0 | 1.0 | 9% | 1.0 | 1.0 |
| Monthly | 40% | 43% | 2.7 (1.5-4.7) | 2.5 (1.4-4.6) | 49% | 7.2 (2.4-21.8) | 7.5 (2.5-22.9) |
| Weekly | 5% | 36% | 19.1 (8.5-43.2) | 19.9 (8.4-46.7) | 42% | 59.1 (16.8-208) | 62.2 (16.8-230) |
*
Odds ratio and 95% confidence intervals adjusted for exact age in years and sex
†
Odds ratio and 95% confidence intervals adjusted for exact age in years, sex, BMI (continuous), pack years smoked (continuous), NSAID use
‡
Analysis restricted to participants aged ≥ 25 years
§
Analysis restricted to participants aged ≥ 35 years
∥
Analysis restricted to participants aged ≥ 55 years